Projects
Using ‘real world’ data to enhance medication safety during pregnancy: towards a ‘fit-for-purpose’ registration system on maternal medication use and mother-infant outcomes (BELpREG) KU Leuven
Evidence on medication safety in pregnancy is lacking for most products, despite their frequent use. As randomized controlled trials cannot be performed in this population, opportunities of ‘real-world’ data collection for pharmacoepidemiologic research should be fully exploited. In 2021, a prototype of a comprehensive registration system on maternal medication use and mother-infant outcomes (BELpREG) was developed at KU Leuven, allowing data ...
Maximising benefit, minimising harm: how individual differences impact the effects of mindfulness meditation KU Leuven
Despite large interindividual differences in efficacy of Mindfulness-Based Interventions (MBIs), it is unknown for whom mindfulness is beneficial, for whom it may be harmful, and why this is the case. Therefore, and given the increasing popularity of mindfulness, personalised effects of mindfulness meditation are not only a timely subject for future research but also a general concern for public health. This project aims to investigate how ...
Development, characterization and validation of an in vitro/in silico platform to predict transfer of medicines to human breast milk along with neonatal systemic exposure to maternal medication. KU Leuven
Breastfeeding has been shown to have short- and long-term benefits regarding chronic diseases, cognitive deficits, infant morbidity and mortality. However, breastfeeding adherence in the EU is low. One of the factors leading to the decision not to breastfeed is the lack of safety information for medicines. It is currently impossible to make evidence-based decisions on the use of maternal medication during breastfeeding. Women are counselled ...
TRPM5 potentiating compounds as novel targets for anri-diabetic medication KU Leuven
Diabetes Mellitus Type 2 is a worldwide epidemic for which cost-effective treatment is still urgently needed. This project focuses on the role of TRPM5 as a novel drug target for Diabetes Mellitus Type 2. More specifically we aim to find compounds that enhance TRPM5 channel activity. In our preliminary work we have found that potentiation of the Ca2+ activated nonselective cation channel TRPM5 improves pancreatic ß-cell function, and thereby ...
Influence of type and place of distal colon descendence and rectum in humans for evaluation of medication efficiency in modeling sensory and motor responses. KU Leuven
Aim of the project is to compare the sensory-motor response of the distal colon and of the rectum to different kinde of distensions and to evaluate the effect of linaclotide on these responses in healthy subjects and in IBS patients.
Narrative, argumentation and multimodality in arts and science mediation Ghent University
The goal of this project is to analyse how, in todayU+2019s highly digitized and networked (post-)covid mediascape, key stakeholders in arts and science are revisiting their traditional ways of mediating their content and are adopting virtual platforms and novel audiovisual media formats. Drawing on linguistic ethnography, I set out to 1. Document novel ways of mediating arts and science and examine shifting underlying conceptualizations of ...
EU conflict mediation in its wider neighbourhood: mapping and explaining the EU’s incoherent involvement in peace-making Ghent University
The proposed research will address the puzzling observation that EU involvement in conflict mediation in its wider neighbourhood is highly inconsistent, whereby it engages in the mediation of some conflicts but not in others. Using a combination of Qualitative Comparative Analysis and process-tracing, it will map the different forms of EU engagement and examine the causal conditions explaining this variation.
Indirect control of soil texture on decomposition of organic matter by mediation of the soil moisture balance - expansion of a field experiment with the factor soil drainage/capillary rise and 13C-pulse-labelling Ghent University
Soils function central ecosystem compartments as emitter of greenhouse gases, reservoir of
nutrients and carbon, water and biota. The dynamics of soil organic matter (SOM) are interlinked
with local as well as global biogeochemical cycles and its study is a research topic of high relevance
agriculturally and environmentally. One key determinant of soil microbial activity is soil texture with
enhanced physical ...
Dealing with multiple mediators in causal mediation analysis Ghent University
Limitations of methods for causal mediation analysis are so severe that they prohibit realistic applications with multiple mediators. To overcome this, we will propose new conceptual definitions of interventional direct and indirect effects, along with estimation procedures. These effects are informative about interventions, require fewer assumptions than current notions of causal effects and can be identified in multiple mediator ...