Projects
Towards Individualised Model-based Monitoring: From Biology to Technology KU Leuven
One of the main obstacles in applying engineering approaches to biological processes remains dealing with inter- and intra-individual differences. Therefore, it is highly challenging to accurately monitor their individual state (cfr. personalised medicine). The general objective of this PhD is to develop a framework for individualised model-based monitoring for biological processes, as inspired by control engineering concepts. The presented ...
New model-based concepts for nano-engineered polymer composites. KU Leuven
A model-based approach to unravel the driving forces in attrition-enhanced deracemization processess. KU Leuven
Molecular chirality is an important geometrical property with far-reaching implications in the pharmaceutical, food and agrochemical industries. Chiral molecules can exist in two non-superimposable mirror-image forms called enantiomers, which often possess substantially different biological effects. Since most chemical synthetic processes of chiral molecules result in an equimolar mixture of both enantiomers, referred to as a racemic mixture, ...
Model-based distributed sensor fusion for MAGV state and parameter estimation KU Leuven
The proposed research deals with indirect methods utilizing the standard set of sensors to estimate or observe vehicle state and/or parameters. Novel model-based approaches will be developed for fusing distributed sensor information with the aim of obtaining online vehicle state and/or parameter estimates. The MAGV (Multi-Actuated Ground Vehicle) subsystems for the estimation purposes will be presented in the form of advanced mechatronic ...
Population Balance Model-Based Optimization of Deracemization Processes for Pharmaceutical Applications KU Leuven
Chirality has different implications in pharmaceuticals, as in some cases, enantiomers exhibit different biological activities and most of the times, only one enantiomer (eutomer) possesses the desired effect. For example, ibuprofen, which is sold as a racemate (1:1 mixture of the two enantiomers R- and S-) under the trade names Advil, Motrin etc. is a drug able to treat pain, fever and inflammation. Even if only the S- enantiomer is ...
Universal Design and design practice: universal design patterns as a model and support for designing integrally and inclusively for all. Hasselt University
Design and design automation of analog and mixed-signal integrated circuits KU Leuven
Microelectronic/nanoelectronic integrated circuits are the underlying technology for the many ICT applications that increasingly impact our daily lives: computing, communication, multimedia, entertainment, transport, healthcare, etc. While more and more applications are becoming digital in nature, analog and mixed analog-digital integrated circuits remain an essential part in electronic systems for the countless applications that interact ...
Blurring the lines between materials design and structural design: Advanced microstructural design of structural fibre-reinforced composites KU Leuven
Blurring the lines between materials design and structural design: Advanced microstructural design of structural fibre-reinforced composites. KU Leuven
Many breakthroughs in traditional materials have been achieved through time-consuming and expensive trial-and-error. To develop the next generation of lightweight composites, a paradigm shift is needed to catalyse their adoption in industry and address current drawbacks. Rather than accepting that the microstructure is a consequence of the manufacturing process, I envision that we should aim to design the microstructure to optimally satisfy ...