Influence of chronic oligemia on neurovascular defects and their relation to the onset and development of neurodegeneration: in vivo evaluation of neurovascular response capacity and metabolism in an Alzheimer mouse model. KU Leuven
Alzheimer’s Disease (AD) is the most common cause of dementia, and the most common neurodegenerative disease. AD patients suffer from age-dependent accumulation of dysfunctional amyloid and tau proteins, leading to the deterioration of neurons. As the disease progresses, cognitive faculties become impaired, eventually resulting in death 4-10 years after diagnosis. The most important risk factor is age, and to the increasing overall age of ...