Projects
Development of advanced fluorescence microscopy methods for studying the structure, transport and stability of nanomedicines for gene therapy of the retinal pigment epithelium Hasselt University
Targeted killing or reprogramming of tumor-associated macrophages with multifunctional nanomedicines Vrije Universiteit Brussel
Targeted depletion or reprogramming of tumour-associated macrophages with engineered nanomedicines Ghent University
This project aims at the development of nanoparticles that are selectively recognized and taken up by tumor associated macrophages (TAMs). This phenotype of macrophages is known for its pro-tumoral activity. Therefore we will engineer nanoparticles to reprogram TAMs into an anti-tumoral phenotype to allow fora n improved anti-cancer treatment.
cytotoxic T cells as transport vehicles for tumor-targeted delivery of nanomedicines Ghent University
Development of advanded fluorescence microscopy methods for studying the structure, the transport and stability of nanomedicines for gene therapy of the retinal pigment epithelium. Ghent University
Several types of nanomecicines are evaluated for deliviry nucleic acids to retinal pigment epithilium (RPE) cells. However, more information is nedded on their stability and transport in biological media like the vitreous gel, retina and inside the RPE dells. In this project we will develop and apply several advanced fluorescence microscopy methods to increase our understanding of their physico chemical properties.
High intensity focused ultrasound and mRNA nanomedicines: a new strategy to induce and boost anti-tumor immunity Vrije Universiteit Brussel
treatment of cancer. Among the recent discoveries in cancer
immunotherapy is the concept of immunogenic cell death (ICD).
When tumor cell death is induced in an immunogenic way, dying
tumor cells can be recognized and engulfed by dendritic cells (DCs),
resulting in DC-activation and tumor antigen presentation. As such,
dying tumor cells can ...
High intensity focused ultrasound and mRNA nanomedicines: a new strategy to induce and boost anti-tumor immunity Ghent University
Cell-based immunotherapies hold great promise for the future treatment of cancer. Among the recent discoveries in cancer immunotherapy is the concept of immunogenic cell death (ICD). When tumor cell death is induced in an immunogenic way, dying tumor cells can be recognized and engulfed by dendritic cells (DCs), resulting in DC-activation and tumor antigen presentation. As such, dying tumor cells can become a cell-based vaccine. This project ...
Nanomedicine: an integrative approach Ghent University
Nanomedicine (NM) is regarded as one of the most promising applications of nanotechnology, as it would allow the development of tailored therapies, with a high level of selectivity and efficacy. Altough much research has been performed over the past decades, translation from academia to commercial application remains disappointingly low. Reasons that explain the current moderate success of NM are: (1) promising preclinical results are often ...