Exploring co-encapsulation of antihistamines and immune checkpoint siRNAs in lipid nanoparticles for cancer immunotherapy. Ghent University
Our group recently showed that cationic amphiphilic drugs (CADs) can complex nucleic acids in lipid nanoparticles (LNPs) for drug combination therapy. This project aims to evaluate this CAD-LNP platform in cancer immunotherapy. Immune checkpoint blockade (ICB), e.g. via PD-L1 antibodies, has demonstrated clinical efficacy, but is hampered by immune-related off-target effects following systemic exposure and low response rates due to an ...