p53 and its novel targets in healthy neurodevelopment and microcephaly, studied in mice. KU Leuven
The tumor suppressor P53 (also named TP53) in humans ((T)p53 in mice) is of pivotal importance for the maintenance of genome stability. About 50% of cancers involve P53 gene mutation, making P53 one of the most extensively investigated genes/proteins. p53 is a transcription factor that can (de)activate genes (“p53 targets”) by binding to specific regulatory DNA sequences. p53 activates genes involved in cell cycle arrest, DNA repair and ...