Projects
From gene to function: Unraveling the molecular mechanisms of Alzheimer-associated ABCA7 risk variants in microglia biology. University of Antwerp
mHealth rehabilitation technology and repeated ecological momentary assessments in people with neurological disorders Hasselt University
Connected speech as an expression of brain health KU Leuven
Understanding somatosensory deficits and the potential of targeted therapy to improve upper limb function in children with unilateral cerebral palsy: a behavioral and neurological approach KU Leuven
Unilateral cerebral palsy (uCP) is a lifelong disorder resulting from a lesion in the developing brain. Besides motor impairments, up to 90% of these children also have somatosensory deficits in the upper limb. As somatosensory information is of utmost importance for coordinated upper limb movements and motor learning, somatosensory deficits may hamper effective use of the impaired upper limb in bimanual daily life activities. However, an ...
Soft integrated ion-based circuits for diagnostics and closed-loop neurological interventions Ghent University
Responsive modulation of neural networks is increasingly being used to treat patients with auditory-neurological disorders and neuropsychiatric diseases. Yet, current technology burdens neurostimulation tools with bulky, non-biocompatible electrical components that require rigid encapsulation for long-term implantation in body. Recently, we created a novel transistor architecture (internal ion-gated organic electrochemical transistors; IGT) ...
3D Dynamic Assessment for Clinical Decision-Making in Adult Spine Deformity Care KU Leuven
Novel platforms for studying AAV subcellular biology & the design of improved gene therapy vectors KU Leuven
Adeno-associated virus (AAV) gene therapy is currently experiencing a renaissance thanks to a number of successful clinical trials. However, vector doses required to achieve therapeutic effect are high and some tissues remain difficult targets for efficient transduction. In general, gene therapy strategies directed at the brain of patients with inherited neurological or neurodegenerative disorders have shown limited efficacy. One of the main ...
The development of a Virtual reality software application to assess and treat visuospatial neglect in centralneurological conditions Karel De Grote Hogeschool
Unlocking Therapeutic Potential: Harnessing Extracellular Vesicles and miRNAs to Combat Muscle Wasting Disorders KU Leuven
Approximately 40% of the human body’s mass is comprised of skeletal muscle, making it the largest organ in the human body. These muscles play a crucial role in providing stability, supporting movement, and maintaining the integrity of internal organs. Importantly, skeletal muscles possess the inherent ability to grow and regenerate, whether in response to injury or as a result of physiological conditions such as exercise. This study explores ...