Projects
CYTOTOXIC THERAPY REVISED: EXPLORATION OF INNOVATIVE (PRO)DRUGS IN PATIENT-DERIVED XENOGRAFTS OF SOFT TISSUE SARCOMA KU Leuven
Soft tissue sarcomas (STS) represent a heterogeneous group of rare, malignant tumors of mesenchymal origin, which comprises more than 80 histological subtypes. Despite their extensive histological and molecular variety, the majority of STS are treated in a rather uniform way, especially in advanced setting. For these patients, doxorubicin has remained the first-line standard-of-care ever since its first introduction in the 1970s. However, ...
Chicken chorioallantoic membrane (CAM) model as a research tool complementary to patient-derived xenografts (PDX) for preclinical drug testing in sarcomas. KU Leuven
Targeting soft tissue sarcoma with smart molecules - exploring cytotoxic prodrugs and target-specific inhibitors in patient-derived xenografts KU Leuven
Soft tissue sarcomas (STS) are malignant tumours that originate in soft tissues, which connect, support and surround body structures and include for example muscle and fat. STS are a group of very diverse and rare tumours. Most STS have an aggressive behaviour, especially if diagnosed when the disease is in a more advanced stage. The current systemic standard therapies have very unsatisfactory effects in most subtypes of STS, with 1-year and ...
EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts KU Leuven
Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker ...
Developing personalized treatment for advanced penile cancer through establishment of Patient-Derived Tumor Xenografts (PDTXs) KU Leuven
Penile cancer exhibits an aggressive clinical course marked by early
lymphatic and visceral dissemination. However, efficacy of platinum-based
regimens is extremely poor and resistance to these therapies develops
rapidly. As a reference centre, we have the opportunity to collect sufficient
patient samples to do meaningful research in this rare cancer. First, we want
to gain a better insight in the molecular and ...
Establishment of an in vivo platform of patient-derived xenografts of several tumor types to study tailored cancer treatment. KU Leuven
This grant application is part of a large and ambitious project designed to set up a comprehensive in vivo platform for the establishment, characterization and preclinical exploration of PDTX of many different tumor types.
Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs). KU Leuven
Penile cancer exhibits an aggressive clinical course marked by early lymphatic and visceral dissemination. However, efficacy of platinum-based regimens is extremely poor and resistance to these therapies develops rapidly. As a reference centre, we have the opportunity to collect sufficient patient samples to do meaningful research in this rare cancer. First, we want to gain a better insight in the molecular and genomic drivers of penile ...
Towards a PD biomarker guided therapy for patients with peritoneal carcinomatosis: combining patient-derived xenograft models and translational PKPD modeling to pave the way for a new paradigm in intraperitoneal chemotherapy Ghent University
Nowadays, patients with tumor metastases in the abdominal cavity are treated, with chemotherapy applied directly in the abdominal cavity, without the proper tools for a physician to follow up on the treatment. This in combination with the current uncertainties with regards to the optimal amount of drug to use and the optimal treatment duration make that, in our opinion, much room is left for improvement of the current implemented ...