Projects
Building molecules using a Unified Computational and Organic Reaction Network (UniCORN). KU Leuven
PhD position - Organic synthesis of fluorinated compounds KU Leuven
The project focuses on the design and applications of reagents for SF5 introduction into small molecules. In a later stage of the work, these reagents will also be applied to radiolabeling and synthesis of analogues of bioactive compounds.
Enabling SF5 introduction: Paving the way toward unexplored bioisosteres and novel PET radiotracers KU Leuven
Organofluorverbindingen nemen steeds meer een gepriviligieerde plaats in als kandidaat-medicijnen, diagnostische PET-tracers en agrochemicaliƫn. Concreet bevatte ongeveer de helft van de door de FDA goedgekeurde kleine molecule geneesmiddelen in 2018 een of meer fluoratomen. De recente ontwikkeling van een veelheid aan stabiele fluortransfer reagentia heeft het arsenaal aan fluorbevattende verbindingen sterk doen uitbreiden. Niettegenstaande ...
Next generation sulfur(VI)-fluoride probes for activity-based protein profiling. KU Leuven
In this work, we will advance reactive molecules ('probes') for the study of proteins. The need for development of new probes stems from the fact that different types of probes bind diverse proteins. Once a protein is tagged, it can be analyzed and identified, and in cases where the enzyme appears to play a role in human diseases, a drug candidate can be developed based on the employed probe. The approach in this project is novel in the ...