Enabling SF5 introduction: Paving the way toward unexplored bioisosteres and novel PET radiotracers KU Leuven
Organofluorine scaffolds hold an increasingly privileged position as drug candidates, diagnostic PET radiotracers and agrochemicals. In fact, about half of the novel FDA-approved small molecules in 2018 contained a fluorinated moiety. Recent development of a plethora of bench-stable transfer reagents for fluorinated functionalities has substantially expanded the arsenal of fluorine-containing molecules at our disposal. Despite these advances, a ...