Function and regulation of the polyamine transporter ATP13A3 in polyamine homeostasis KU Leuven
Polyamines are physiologically important cations that support vital cell functions, but their levels decline with ageing. A disturbed polyamine homeostasis is implicated in ageing-related disorders, whereas polyamine supplementation promotes longevity. Cells acquire polyamines via biosynthesis, or via uptake through the polyamine transport system (PTS). We recently established ATP13A3 as a major component of the PTS that is genetically ...