Selective vulnerability in Alzheimer’s disease and frontotemporal degeneration: integration of postmortem MRI, mass-spectrometry and histopathology KU Leuven
Understanding selective vulnerability is one of the most fundamental challenges in the field of neurodegenerative disease. While structural MRI is widely used in clinical diagnostic settings, it lacks more fine-grained information on the nature of the observed atrophy. The current proposal aims for a multidisciplinary integration of postmortem MRI with in-depth protein and cellular analyses using histopathology and mass-spectrometry. The ...