Projects
Transcriptome-based management of transplant-related pulmonary fibrosis in chronic pulmonary rejection after lung or allogeneic stem cell transplantation KU Leuven
Background Chronic lung allograft dysfunction (CLAD) and chronic pulmonary graft versus host disease (cGvHD) are life-threatening conditions commonly encountered after lung transplantation and allogeneic hematopoietic stem cell transplantation. Pathophysiological and molecular pathways associated with transplant-related pulmonary fibrosis leading to structural changes and lung failure in CLAD pulmonary cGvHD remain unknown. Aims The primary ...
Modern technologies in the assessment and treatment of pelvic organ prolapse - experimental and clinical studies KU Leuven
In this project, we aim to use modern assessment techniques to study certain risk factors related to the development of pelvic floor prolapse in a clinical setting as well as in an experimental model. Pelvic floor prolapse is a bothersome condition when the vaginal wall or the uterus protrudes through the vaginal opening. It affects mainly women who were at least once pregnant and delivered vaginally. The project includes clinical part during ...
Novel strategies to increase the number and quality of donor lungs for transplantation KU Leuven
Lung transplantation is a lifesaving treatment option in well-selected patient with end-stage lung disease. Due to the successes of lung transplantation, transplant programs are expanding rapidly worldwide. However, two major problems impede optimal outcome early after lung transplantation. First, 10 to 30% of all lung recipients develop primary graft dysfunction, which is the leading cause of early morbidity and mortality after lung ...
Assessment and management of donor lungs for transplantation KU Leuven
Lung transplantation (Ltx) is the only life-saving treatment for selected patients with end-stage pulmonary disease. Donor organ shortage and primary graft dysfunction (due to ischemia-reperfusion injury) are two major obstacles in the early stages of LTX that might limit the outcome. Therefeore, optimization of donor organ quality and expansion of the donor pool are crucial.
The first objective of this research proposal is to ...