Projects
The role of functional imaging and molecular profiling in image guided highly conformal radiotherapy for head and neck cancer: towards a patient tailored treatment. KU Leuven
Discovery of renal biomarkers to detect early chronic kidney disease in cats Ghent University
This research project aims to identify novel diagnostic and prognostic biomarkers for the early detection of feline chronic kidney disease (CKD). CKD is a frequently encountered disease in veterinary practices, affecting at least 30% of cats over 15 years of age. Current diagnostic tests only detect CKD once there is extensive damage, so it is of significant clinical and commercial importance to diagnose CKD at an earlier stage. This way, ...
The role of TOP3B in AR-mediated transcription and genomic stability in prostate cancer. KU Leuven
Prostate cancer is the second most commonly diagnosed cancer in men, with an estimated 1.1 million diagnoses worldwide in 2012, accounting for 15% of all cancers diagnosed. The clinical diagnosis of prostate cancer is based on three clinical features, which are the digital rectal examination (DRE), prostate-specific antigen (PSA) measurements and prostate biopsies. When diagnosed, prostate cancer is known to be a disease with highly variable ...
Rectal sampler for metabotyping of overweight and obese children towards early prevention and prognosis of metabolic diseases Ghent University
Today’s children are increasingly facing metabolic-related health issues, among which the worldwide prevalence of overweight and obesity is rising at an alarming pace. Childhood obesity is associated with the early onset of chronic diseases including an emergence of prediabetes and diabetes mellitus type 2. The decline of insulin sensitivity already years before puberty, exposes children to long-term complications prior the appearance of ...
'No world without the stars': Astrology and Society in the SpanishHabsburg Netherlands during the Dutch Revolt (1560s-1640s). University of Antwerp
The long-term legacy of prolonged critical illness in the muscle: mechanisms and clinical impact. KU Leuven
Patients who experience life-threatening illnesses – including major trauma, surgery, medical illness, and severe burns – are cared for at intensive care units (ICUs). Advances in critical care have decreased acute mortality, but in parallel, the proportion of patients requiring prolonged intensive care to overcome vital organ dysfunction has increased. Patients surviving critical illness unfortunately continue to face increased mortality ...
'No world without the stars': Astrology and Society in the SpanishHabsburg Netherlands during the Dutch Revolt (1560s-1640s). University of Antwerp
Machine learning to predict cardiovascular events and response to therapy based on echocardiographic-derived functional and morphological characteristics of the heart. KU Leuven
Cardiovascular disease remains a major health problem worldwide, as it is responsible for about 30% of all deaths. When diagnosing the heart, ultrasonic imaging remains the modality of choice not only due to the fact that it is non-invasive, mobile and relatively cheap but also because it can generate images in real-time and at a high rate (e.g. conventionally about 30 images/second can be generated). Although worldwide a lot of research ...
Development of a microfluidic platform for self-governing selection of individual B-cells using bioresponsive hydrogels: a source of fully human therapeutic antibodies KU Leuven
Monoclonal antibodies (mAb) are the biggest class of biopharmaceuticals used against cancer, inflammatory and autoimmune diseases. As the ability of the human immune system to generate highly specific mAb is unmatched by any man-made approach, several technologies have been developed to generate fully human (FH)-mAb. Among those, single B-cell screening has emerged as a powerful technique. In this project, two KU Leuven groups will join their ...