Induction of programmed cell death by synergistic modulation of glycolytic flux and Ras activity in yeast and cancer cells KU Leuven
Catabolic breakdown of glucose through glycolysis is one the most ancient and conserved ways to fuel and maintain bioenergetic homeostasis. Both yeast and cancer cells ferment glucose to ethanol or lactate, respectively, to support vigorous cell division. Cancerous growth poses an important threat to human health as currently millions of people yearly succumb to its consequences. Fast proliferating cancer cells often rely on strong glucose ...