Drug-target identification by rapid selection of drug resistance mutations KU Leuven
The present invention relates to methods used in functional genomics that focus on gene function in a cell. The invention also relates to mutagenizing genes and generation of functional genetic mutants. The current invention also relates to methods for stimulus/drug-target identification. In addition, the invention relates to the generation of cell lines showing a functional phenotype, most notably stimulus/drug-resistant cell lines. The current invention further relates to methods for identification of mutations conferring this phenotype. The current invention further relates to said methods ...