Projects
Somatic mutations explain missing risk of multiple sclerosis. KU Leuven
Somatic mutations explain missing risk in multiple sclerosis
An Goris, Laboratory for Neuroimmunology, KU Leuven
1. State of the art
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, affecting 2.5 million
people worldwide and leading to important physical and cognitive disability with typical onset during
young adulthood. A genetic component has long been demonstrated and through ...
TEM nano-statistics investigations of structural defects in nanostructured materials under static and dynamic loading. University of Antwerp
Interoceptive categorisation and symptom perception KU Leuven
Perceived sensations and symptoms often correspond poorly to the physiological state of the body. We proposed that the categorisation of bodily sensations (e.g., into categories of benign sensations vs. physical symptoms) is involved in this decoupling and may in extreme cases result in the perception of somatic symptoms in the absence of clear organic dysfunction – or functional somatic symptoms. More specifically, we expected that enhanced ...
Regulation of Self−Renewal, differentiation and Reprogramming through Wnt/B-catenin and the Tcf/Lef factors. KU Leuven
Activation of Wnt signaling can drive embryonic stem cells into opposite directions: self−renewal or ESCs differentiation. Futhermore we have demonstrated that a tuned regulation of the pathway also increase somatic cell reprogramming. How activation of the same Wnt/β−catenin signal yields disparate effects in different cell types, remains poorly understood. I hypothesize that the difference lies in the downstream effectors of the ...
SLOW, DEEP BREATHING TO DAMPEN PAIN: EVALUATING THE EFFICACY AND INVESTIGATING THE UNDERLYING PSYCHOPHYSIOLOGICAL MECHANISMS KU Leuven
Pain is the most common symptom for which people seek medical care. Chronic pain is common worldwide, and often not treated adequately, thereby leading to reduced quality of life and high healthcare costs. Recently, there has been increasing attention toward the complexity and biopsychosocial nature of pain, and the need for multidisciplinary pain management has been increasingly acknowledged. Various mind-body interventions are being used ...