Investigating the effect of the solvent on the physical structure and phase behavior of amorphous solid dispersions manufactured with spray drying KU Leuven
Over the past years, the number of poorly soluble drugs has significantly increased, resulting in low and variable oral bioavailability. To address this problem, a promising strategy is to disperse the drug at the molecular level in an inert polymeric carrier, which is known as an amorphous solid dispersion (ASD). One of the most commonly used manufacturing methods for ASDs is spray drying. Several commercial ASD formulations have been ...