Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity Ghent University
In recent years, immunotherapy is being increasingly used for the treatment of cancer patients. So far, treatments that involve T cells, including immunological checkpoint blockade and adoptive cellular therapy, have been the main focus of most immunotherapies. However, natural killer (NK) cells are receiving renewed interest as they have the considerable advantage of not relying on antigen specificity. Of the different therapeutic strategies that involve NK cells, one is the in vitro differentiation of cord blood-derived hematopoietic stem cells (HSC) into mature NK cells, that are then ...