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Application of thermal inactivation of enzymes during vitamin C analysis to study the influence of acidification, crushing and blanching on vitamin C stability in Broccoli (Brassica oleracea L var. italica) KU Leuven

Ann Van Loey, Marc Hendrickx
The effectiveness of heat inactivation of oxidative enzymes e.g., ascorbic acid oxidase (AAO) to stabilise vitamin C during extraction and analysis was evaluated. The influence of different sequences of performing treatments including acidification (pH 4.3 vs. pH 6.5), crushing, high temperature short time (90 degrees C/4 min-HTST) and low temperature long time (60 degrees C/40 min-LTLT)) blanching on vitamin C stability in broccoli florets and ...

Salivary 8-hydroxy-2-deoxyguanosine, malondialdehyde, vitamin C, and vitamin E in oral pre-cancer and cancer: diagnostic value and free radical mechanism of action KU Leuven

Jasdeep Kaur, Constantinus Politis, Reinhilde Jacobs
OBJECTIVES: The objectives of this study are to analyze oxidative DNA and lipid damage using salivary 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and vitamins C and E in oral lichen planus lesions, oral leukoplakia, oral submucous fibrosis, oral squamous cell carcinoma (SCC), and controls and to determine the value of salivary biomarkers in the diagnosis of oral pre-cancer and cancer patients. MATERIALS AND METHODS: Unstimulated ...

Antioxidant vitamin status (A, E, C, and Beta-Carotene) in European adolescents : the HELENA Study Ghent University

Christina Breidenassel, Jara Valtuena, Marcela Gonzalez-Gross, Jasmin Benser, Andre Spinneker, Luis A Moreno, Stefaan De Henauw, Kurt Widhalm, Denes Molnar, Guiseppe Maiani, et al.
Background: An adequate nutritional status of antioxidant vitamins (vitamins A, C, E) and beta-carotene is essential especially during childhood and adolescence, because of their important roles in cell growth and development. Currently, there are no physiological reference values for blood concentration of these vitamins and beta-carotene in apparently healthy European adolescents. The aim of the current study was to obtain reliable and ...

Furan formation in baby food model system from vitamin C and unsaturated fatty acids Ghent University

Agnieszka Owczarek-Fendor, Bruno De Meulenaer, Georges Scholl, Pratheeba Yohendrarajah, An Adams, Fien Van Lancker, Gauthier Eppe, Edwin De Pauw, Marie-Louise Scippo, Norbert De Kimpe, et al.
Furan, classified as “possibly carcinogenic” to humans in Group 2B by IARC has been found in an unexpected number of heat treated foods. The furan generation has been associated with thermal degradation of vitamin C, carbohydrates, proteins, and polyunsaturated fatty acids via formation of multiple reactive carbonyl species. In this study, the furan formation in vitamin C and fats containing model food systems similar to baby food was ...

Dosing vitamin C in critically ill patients with special attention to renal replacement therapy Vrije Universiteit Brussel

Patrick Honoré, Herbert Spapen, Paul E Marik, Willem Boer, Heleen M Oudemans-van Straaten

RATIONALE/METHODS: The primary aim of the present contribution is to find a literature-based agreement on dose adjustments of vitamin C in critically ill patients undergoing renal replacement therapy (RRT).

AVAILABLE DATA/STUDY RESULTS: Critical illness is frequently accompanied by severe vitamin C deficiency. High-dose supplementation beneficially affects clinical outcome in small cohorts of patients with sepsis, burn injury, and ...

Early administration of Vitamin C in patients with sepsis or septic shock in emergency departments Vrije Universiteit Brussel University of Antwerp KU Leuven

Stefanie Vandervelden, Lina Wauters, Jan Breuls, Steffen Fieuws, Philippe Vanhove, Ives Hubloue, Magali Bartiaux, Jacques Creteur, François Stifkens, Koen Monsieurs, et al.

BACKGROUND: Sepsis is a potentially life-threatening condition characterized by a deregulated body's response to infection causing injury to its own tissues and organs. Sepsis is the primary cause of death from infection. If not recognized and treated timely, it can evolve within minutes/hours to septic shock. Sepsis is associated with an acute deficiency of Vitamin C. Despite the proof-of-concept of the benefit of administering Vitamin C in ...

Oral vitamin C administration increases lipid peroxidation in hemodialysis patients Ghent University

An S. De Vriese, Danielle Borrey, Els Mahieu, Ilse Claeys, Lut Stevens, Ann Vanhaeverbeke, Mieke Roelens, Michel Langlois
Background: Since vitamin C (ascorbic acid, AA) deficiency is common in hemodialysis patients, systematic supplementation has been recommended. Further, vitamin C has been advocated as a potential adjuvant to erythropoietin by virtue of its capacity to improve iron utilization. However, vitamin C may have a paradoxical pro-oxidant effect in the presence of iron. Methods: In 109 hemodialysis patients, oral vitamin C was administered at 360 and ...

Vitamin C deficiency: more than just a nutritional disorder Ghent University

Joris Delanghe, Michel Langlois, Marc De Buyzere, Na Na, Jin Ouyang, Marijn Speeckaert, Mathieu Torck
Although vitamin C deficiency and scurvy are generally considered as pure nutritional disorders, only a minority of the vitamin C concentration is determined by food intake. In the presence of transition metals (iron and copper), the antiscorbutic factor shifts from an antioxidant to a pro-oxidant function. Haptoglobin (Hp) is a plasma alpha-2 glycoprotein characterized by 3 common phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). Its free hemoglobin ...