Onderzoeker
Dean PAES
- Trefwoorden:Biomedische wetenschappen
- Disciplines:Genoomstructuur en -regulatie, Celgroei en -ontwikkeling, Cellulaire signaaltransmissie, Epigenetica, Genetica, Intracellulaire compartimenten en transport, Transcriptie en translatie, Biomarker ontdekking, Compound screening, In vitro testen
Affiliaties
- Neurowetenschappen (Departement)
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Vanaf1 jan 2020 → Heden - Neurowetenschappen (Onderzoeksgroep)
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Vanaf1 jan 2020 → Heden - Biomedisch Onderzoeksinstituut (Onderzoeksinstituut)
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Vanaf16 jun 2017 → Heden - Geneeskunde en Levenswetenschappen (Faculteit)
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Vanaf16 jun 2017 → Heden - Fysiologie - biochemie - immunologie (Departement)
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Vanaf16 jun 2017 → 31 dec 2019 - Immunologie - Biochemie (Onderzoeksgroep)
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Vanaf16 jun 2017 → 31 dec 2019
Publicaties
1 - 10 van 12
- Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-beta pathology(2023)
Auteurs: Dean PAES, Melissa SCHEPERS, Emily WILLEMS, Ben ROMBAUT, Assia TIANE, Yevgeniya Solomina, Amy Tibbo, Connor Blair, Elka Kyurkchieva, George S. Baillie, et al.
- Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis(2023)
Auteurs: Melissa SCHEPERS, Dean PAES, Assia TIANE, Ben ROMBAUT, Elisabeth PICCART, Lieve VAN VEGGEL, Pascal GERVOIS, Chiara Brullo, Olga Bruno, Ernesto Fedele, et al.
Pagina's: 1 - 22 - Computational investigation of the dynamic control of cAMP signaling by PDE4 isoform types(2022)
Auteurs: Dean PAES, Sammy Hermans, Daniel van den Hove, Tim VANMIERLO, Jos Prickaerts, Aurelie Carlier
Pagina's: 2693 - 2711 - PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity(2021)
Auteurs: Ben ROMBAUT, Sofie KESSELS, Melissa SCHEPERS, Assia TIANE, Dean PAES, Yevgeniya Solomina, Elisabeth PICCART, Daniel van den Hove, Bert BRONE, Jos Prickaerts, et al.
Pagina's: 2080 - 2097 - Increased isoform-specific phosphodiesterase 4D expression is associated with pathology and cognitive impairment in Alzheimer’s disease(2021)
Auteurs: Dean PAES, Roy Lardenoije, Riccardo CAROLLO, Janou A. Y. Roubroeks, Melissa SCHEPERS, Paul Coleman, Diego Mastroeni, Elaine Delvaux, Ehsan Pishva, Katie Lunnon, et al.
Pagina's: 56 - 64 - The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors(2021)
Auteurs: Dean PAES, Melissa SCHEPERS, Ben ROMBAUT, Daniel van den Hove, Tim VANMIERLO, Jos Prickaerts, Martin Michel
Pagina's: 1016 - 1049 - Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory(2021)
Auteurs: Susan McQuown, Dean PAES, Karsten Baumgartel, Jos Prickaerts, Marco Peters
- Relieving the epigenetic blockade in progressive multiple sclerosis - making remyelination accessible again(2019)
Auteurs: Assia TIANE, Melissa SCHEPERS, Dean PAES, J. Prickaerts, D. van den Hove, Niels HELLINGS, Tim VANMIERLO
Pagina's: E444 - E444 - Phosphodiesterase Type 4 Inhibition in CNS Diseases(2019)
Auteurs: A Blokland, P Heckman, Tim VANMIERLO, R Schreiber, Dean PAES, J Prickaerts
Pagina's: 971 - 985 - Phosphodiesterase 4D inhibition boosts remyelination in multiple sclerosis(2019)
Auteurs: Melissa SCHEPERS, Dean PAES, Assia TIANE, Els HOUBEN, O. Bruno, C. Brullo, Niels HELLINGS, J. Prickaerts, Tim VANMIERLO
Pagina's: E656 - E657