Electron Transport Chain

© 2017 Elsevier Inc. All rights reserved.. The protein complexes that comprise the electron transport chain (ETC) fuel the production of ATP, the universal biochemical energy currency. Defects in ETC function have widespread consequences and are linked to neurodegenerative diseases, including Parkinson's disease (PD). Defects in NADH:ubiquinone oxidoreductase, the first complex in the ETC, have been found in both sporadic and familial cases of PD. Here, we list the evidence for the role of ETC dysfunction in the pathogenesis of PD and highlight how therapeutic approaches aimed at stimulating electron transport could be beneficial for both familial and sporadic cases of PD.

ISBN:978-0-12-803783-6

Jaar van publicatie:2017