A first insight on the bio-functionalization mechanisms of TiO2 nanotubes with calcium, phosphorous and zinc by reverse polarization anodization

© 2017 Elsevier B.V. The decoration of titanium (Ti) implant surfaces with TiO 2 nanotubes has emerged as a promising strategy to improve osseointegration and avoid infection. Nevertheless, it has been reported that nanotubular films are prone to peeling off from the Ti substrate due to the poor interfacial adhesion. The knowledge on the interfacial properties of such interface, although not well explored, is crucial for understanding the mechanisms behind the poor adhesion problem of these films and to further achieve an easy and effective solution to solve it. This paper is focused on the bio-functionalization of TiO 2 nanotubular films with zinc (Zn) as an antimicrobial and bone healing agent, together with two major components of bone matrix, namely calcium (Ca) and phosphorous (P). The main aim is, for the first time, the thorough characterization of the interface between TiO 2 nanotubes and the Ti substrate, along with the better understanding of the bio-functionalization mechanisms of TiO 2 nanotubes and their influence on the interfacial features of the films. TiO 2 nanotubes were successfully synthesized by two-step anodization and their bio-functionalization with Ca, P and Zn was achieved by reverse polarization anodization treatments. The in-depth characterization of the morphological and chemical features of TiO 2 nanotubes was carried out along their length by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), before and after bio-functionalization treatments. STEM images showed that the interface between conventional TiO 2 nanotubes and Ti is non-continuous due to the existence of a hollow space. However, bio-functionalized TiO 2 nanotubes evidenced an interface with different features, due to the formation of an interfacial oxide film as a consequence of anodization, with a thickness comprised between 230 and 250 nm. The results presented in this work may inspire the emergence of novel surface treatment strategies seeking the long-term performance of metallic-modified osseointegrated implants.

Jaar van publicatie:2017

BOF-keylabel:ja

IOF-keylabel:ja

BOF-publication weight:1

CSS-citation score:1

Auteurs:International

Authors from:Higher Education