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Drug disposition and modelling before and after gastric bypass: immediate and controlled-release metoprolol formulations

Tijdschriftbijdrage - Tijdschriftartikel

The aim of the present study was to evaluate the disposition of metoprolol after oral administration of an immediate and controlled-release formulation before and after Roux-en-Y gastric bypass (RYGB) surgery in the same individuals and to validate a physiologically based pharmacokinetic (PBPK) model for predicting oral bioavailability following RYGB.
Tijdschrift: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
ISSN: 0306-5251
Issue: 5
Volume: 80
Pagina's: 1021 - 30
Jaar van publicatie:2015
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:2
Auteurs:International
Authors from:Higher Education
Toegankelijkheid:Closed