NMR study on the interaction of the conserved CREX 'stem-loop' in the hepatitis E virus genome with a naphthyridine-based ligand

A 2-amino-1,8-naphthyridine derivative that is described to bind single guanine bulges in RNA-DNA and RNA-RNA duplexes was synthesized and its interaction with the single G bulge in the conserved CREX of the Hepatitis E Virus (HEV) genome was explored by NMR and molecular modeling. Results indicate that the ligand intercalates in the internal loop, though none of the expected hydrogen bonds with the single G in the bulge could be demonstrated.

Jaar van publicatie:2015

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BOF-publication weight:1

CSS-citation score:1

Authors from:Higher Education

Toegankelijkheid:Open