Onderzoeker

Waleed Marei

Onderzoeksexpertise:Ongoing studies: - Maternal obesity and "fetal programming": the consequences for reproductive physiology of the offspring. - Fundamental understanding and development of preconception care strategies to improve maternal fertility and to protect offspring's health in obese individuals - Development of polymeric nanoparticle carriers for targeted drug delivery to oocytes. - Protective and reparative strategies to improve oocyte developmental capacity under metabolic stress conditions.

Trefwoorden:LIPIDENPEROXIDATIE, CELCULTUREN, MITOCHONDRIAAL ONDERZOEK, EMBRYONALE ONTWIKKELING, OXIDATIEVE STRESS, ENDOCRIENE PROGRAMMERING, METABOLISME, EICELKWALITEIT, Diergeneeskunde

Disciplines:Dierlijke ontwikkelings- en reproductieve biologie, Reproductieve geneeskunde, Metabole ziekten, Foetale ontwikkeling, Veterinaire reproductie en verloskunde, Fertiliteit

Onderzoekstechnieken:- Bovine and murine in vitro embryo production - Oviductal and endometrial cell culture - Immunohistochemical staining and confocal microscopy - Microfluorimetric determination of cellular metabolic activity - Assessment of oxidative stress and apoptosis - qRT-PCR - WB - ELISA - RIA - Biostatistics

Gebruikers van onderzoeksexpertise:Clinicians and research groups focusing on obesity, metabolic syndrome, diabetes, infertility, pregnancy losses, and long term epigenetic effects on postnatal health. IVF and embryo transfer companies and researchers aiming to improve oocyte and embryo quality and maximize blastocyst yield, blastocyst quality and freezability.