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Publicatie
Same-day imaging using small proteins
Tijdschriftbijdrage - Tijdschriftartikel
Ondertitel:Clinical experience and translational prospects in oncology
Imaging of expression of therapeutic targets may enable stratification of patients for targeted treatments. The use of small radiolabeled probes based on the heavy-chain variable region of heavy-chain–only immunoglobulins or nonimmunoglobulin scaffolds permits rapid localization of radiotracers in tumors and rapid clearance from normal tissues. This makes high-contrast imaging possible on the day of injection. This mini review focuses on small proteins for radionuclide-based imaging that would allow same-day imaging, with the emphasis on clinical applications and promising preclinical developments within the field of oncology.
Tijdschrift: Journal of Nuclear Medicine (The)
ISSN: 0161-5505
Issue: 6
Volume: 59
Pagina's: 885-891
Jaar van publicatie:2018
Trefwoorden:Affibody, Nanobody, Radionuclide molecular imaging, Scaffold proteins
BOF-keylabel:ja
BOF-publication weight:10
CSS-citation score:4
Auteurs:International
Authors from:Higher Education
Toegankelijkheid:Open