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Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review

Tijdschriftbijdrage - Review Artikel

Ondertitel:Structure-functional activity relationship of beta-glucans from the perspective of immunomodulation : a mini-review
β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. β-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, β-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological functions. The mechanisms behind this are not fully understood. This mini-review provides a comprehensive and up-to-date commentary on the relationship between β-glucans' structure and function in relation to their use for immunomodulation.
Tijdschrift: FRONTIERS IN IMMUNOLOGY
ISSN: 1664-3224
Volume: 11
Jaar van publicatie:2020
Toegankelijkheid:Open