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Biocompatibility of resin-based dental materials: Relating exposure to cell responses

Boek - Dissertatie

Every year, resin-based dental restorative materials are used as the standard material in hundreds of millions of patients to restore tooth tissue lost due to trauma or caries. With their increased use, concerns about their potential health risks have been raised. Even though adverse effects induced by dental materials are believed to be infrequent and mild, many individuals potentially may be affected considering the number of patients treated with these materials. However, there is no clear clinical evidence that these restorations materials may cause serious adverse effects. Not only patients but also dental personnel is to a certain extent exposed to compounds of restorative materials. Only occasionally, restorations with composites have been associated with acute reactions, like contact dermatitis, pulp toxicity or allergic reactions. Nevertheless, polymerization of the methacrylate groups in these resin-based dental materials is never complete and unreacted compounds can leach from the materials into the oral environment. Several of these methacrylate monomers are very reactive in nature and have been associated with cytotoxicity, genotoxicity and even reproductive toxicity in in-vitro experiments The aim of this PhD was to investigate the potential health risk factors associated with the use of resin-based dental materials, (1) by assessing the exposure to compounds leached from these materials (analytical research); (2) by examining the associated toxic effects in cells (toxicological research). The objective of this toxicological in-vitro research is threefold: (i) to analyze the exposure to compounds released from resin-based dental materials, (ii) to assess the different types of cell responses to compounds released from resin-based dental materials, and (iii) to evaluate alternatives and improvements to resin-based dental materials to reduce exposure.
Jaar van publicatie:2019
Toegankelijkheid:Closed