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Except for C-C chemokine receptor 7 expression, monocyte-derived dendritic cells from patients with multiple sclerosis are functionally comparable to those of healthy controls

Tijdschriftbijdrage - Tijdschriftartikel

Background aims Dendritic cell (DC)-based immunotherapy has shown potential to counteract autoimmunity in multiple sclerosis (MS). Methods We compared the phenotype and T-cell stimulatory capacity of in vitro generated monocyte-derived DC from MS patients with those from healthy controls. Results Except for an increase in the number of C-C chemokine receptor 7expressing DC from MS patients, no major differences were found between groups in the expression of maturation-associated membrane markers or in the in vitro capacity to stimulate autologous T cells. Conclusions Our observations may pave the way for the development of patient-tailored DC-based vaccination strategies to treat MS.
Tijdschrift: Cytotherapy
ISSN: 1465-3249
Volume: 16
Pagina's: 1024 - 1030
Jaar van publicatie:2014
Trefwoorden:A1 Journal article
BOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:1
Authors from:Government
Toegankelijkheid:Closed