Zinc(II)-catalyzed synthesis of propargylamines by coupling aldimines and ketimines with alkynes

A Zn-II-catalyzed reaction between imines, which were derived from unactivated aldehydes or ketones and primary amines or -amino acid esters, and terminal alkynes has led to the rapid and efficient formation of tri- and tetrasubstituted propargylamines (from aldimines and ketimines, respectively) in good to excellent yields. No additives or extra Lewis acid reagents were required for the imine-alkyne coupling reaction.

Jaar van publicatie:2018

Trefwoorden:A1 Journal article

BOF-keylabel:ja

BOF-publication weight:1

CSS-citation score:2

Auteurs:International

Authors from:Higher Education

Toegankelijkheid:Open