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Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy

Tijdschriftbijdrage - Review Artikel

Ondertitel:Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy

Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. Despite the arsenal of defense strategies against foreign invaders, myeloid cells succumb to the instructions of an established tumor. Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression.

Tijdschrift: Front Immunol.
ISSN: 1664-3224
Issue: 1395
Volume: 11
Pagina's: 1-14
Jaar van publicatie:2020
  • PubMed Central Id: PMC7363805
  • ORCID: /0000-0003-4454-9823/work/83321933
  • ORCID: /0000-0003-2045-6729/work/83321499
  • ORCID: /0000-0001-9671-4363/work/83321467
  • ORCID: /0000-0002-5649-0382/work/83321458
  • ORCID: /0000-0002-9065-1549/work/83320583
  • ORCID: /0000-0002-4442-7474/work/83320481
  • DOI: https://doi.org/10.3389/fimmu.2020.01395
  • WoS Id: 000555576500001
  • Scopus Id: 85088435969
CSS-citation score:1
Toegankelijkheid:Open