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Publicatie

Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

Tijdschriftbijdrage - Brief

Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation.
Tijdschrift: Journal of Inflammation Research
ISSN: 1178-7031
Volume: 14
Pagina's: 4503 - 4507
Jaar van publicatie:2021
Trefwoorden:COPD, pCRP, mCRP, Dlow-grade systemic inflammation
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:2
Auteurs:International
Authors from:Higher Education, Hospital
Toegankelijkheid:Open