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Molecular imaging of apoptosis

Tijdschriftbijdrage - e-publicatie

Ondertitel:the case of caspase-3 radiotracers
The molecular imaging of apoptosis remains an important method for the diagnosis and monitoring of the progression of certain diseases and the evaluation of the efficacy of anticancer apoptosis-inducing therapies. Among the multiple biomarkers involved in apoptosis, activated caspase-3 is an attractive target, as it is the most abundant of the executioner caspases. Nuclear imaging is a good candidate, as it combines a high depth of tissue penetration and high sensitivity, features necessary to detect small changes in levels of apoptosis. However, designing a caspase-3 radiotracer comes with challenges, such as selectivity, cell permeability and transient caspase-3 activation. In this review, we discuss the different caspase-3 radiotracers for the imaging of apoptosis together with the challenges of the translation of various apoptosis-imaging strategies in clinical trials.
Tijdschrift: International journal of molecular sciences
ISSN: 1422-0067
Volume: 22
Jaar van publicatie:2021
Trefwoorden:A1 Journal article
Toegankelijkheid:Open