Carbonylation Chemistry Applied to the Synthesis of Benzimidazo[2,1-b]quinazolin-12-ones

A carbonylative route towards the synthesis of benzimidazo[2,1-b]quinazolin-12-ones was developed. The key step in this strategy consists of an intramolecular carbonylative lactam formation, starting from N-(2-bromophenyl)-1H-benzimidazol-2-amines. These precursor molecules were synthesized by two different methods to introduce a variety of substituents on the aromatic ring systems. Interestingly, only near-stoichiometric amounts of carbon monoxide were required in the ring-closing aminocarbonylation reaction, rendering the developed strategy also suitable for late-stage 13C-isotopic labelling.

Jaar van publicatie:2022

Toegankelijkheid:Closed