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What causes cognitive decline after treatment for breast cancer? A multiparametric neuroimaging study

Boek - Dissertatie

Cognitive impairment has been recognized as a possible adverse effect of breast cancer and its treatment. The aim of the proposed project is to refine earlier findings of the neural correlates of chemotherapy-induced cognitive impairment using multi-model PET-MRI imaging. This to visualize neuroinflammation and specify white matter microstructural changes, in combination with in-depth neurocognitive testing and measurement of biomarkers reflecting peripheral (neuro)inflammation and axonal damage. Defining biomarkers of chemotherapy-induced neurotoxicity will be of crucial importance for future development of cancer drugs and assessing a patient's vulnerability to develop complaints. In this way, treatments can be made to meet an individuals' needs and the quality of life of these survivors can be optimized.
Jaar van publicatie:2022
Toegankelijkheid:Open