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Biomolecules Covalently Anchored on Titanium using Electrophoretic Deposition

Boek - Dissertatie

With the most prominent causes of orthopedic/dental implant failure being loosening and infection, research is focusing on developing surface coatings that either trigger faster and stronger integration in the host bone (i.e. osseointegration) or that render the surface resistant to contaminating micro-organisms. Within this project, novel implant coatings will be developed that consider both approaches simultaneously. Recently, permanently attached coatings of biologically active molecules have gained interest owing to an improved stability and long-term activity of the molecules as well as a reduced cytotoxicity and antibiotic resistance development risk. However, common chemical grafting techniques are relatively slow processes depending on the passive diffusion of biomolecules towards the substrate surface. To accelerate the immobilization process, we propose to actively concentrate the biomolecules at the (metallic) implant surface by means of electrophoretic deposition (EPD). Applying alternating current (AC) signals with an asymmetrical wave shape is a promising new approach enabling EPD from aqueous systems, required for processing biomolecules. However, a fundamental understanding of how to control the deposition yield or how the AC-EPD process might affect the conformation of the biomolecules, and hence their biological activity, is imperative to enable a potential application with clinically relevant biomolecules. Therefore, this project aspires to unravel the links between various key AC-EPD parameters on the process performance followed by validating the clinical utility of AC-EPD immobilized coatings.
Jaar van publicatie:2022
Toegankelijkheid:Closed