Onderzoeker
Paul Coucke
- Disciplines:Genetisch gemodificeerde dieren
Affiliaties
- Vakgroep Biomoleculaire Geneeskunde (Departement)
Lid
Vanaf1 okt 2018 → Heden - Vakgroep Pediatrie en genetica (Departement)
Lid
Vanaf1 okt 2002 → 30 sep 2018
Projecten
11 - 12 of 12
- Gepersonaliseerde functionele genomica in Mendeliaanse ziekten: van DNA varianten klinische en bio-ethische implicatiesVanaf1 jan 2015 → 30 sep 2021Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Zebravis platform voor het testen van de pathogeniciteit van humane ziekte-geassocieerde variantenVanaf1 jun 2014 → 30 nov 2015Financiering: IOF - Industrieel Onderzoeksfonds
Publicaties
1 - 10 van 56
- Retained chromosomal integrity following CRISPR-Cas9-based mutational correction in human embryos(2023)
Auteurs: Bieke Bekaert, Annekatrien Boel, Lisa De Witte, Winter Vandenberghe, Mina Popovic, Panagiotis Stamatiadis, Gwenny Cosemans, Athina-Maria De Loore, Susana Marina Chuva de Sousa Lopes, Petra De Sutter, et al.
Pagina's: 2326 - 2341 - Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for Osteogenesis Imperfecta(2023)Volume: 7
Auteurs: Sophie Debaenst, Hanna De Saffel, Jan Willem Bek, Adelbert De Clercq, Tamara Jarayseh, Lauren Sahd, Paul Coucke, Andy Willaert
Aantal pagina's: 1 - Assisted oocyte activation does not overcome recurrent embryo developmental problems(2023)
Auteurs: Arantxa Cardona Barberán, Davina Bonte, Annekatrien Boel, Vanessa Thys, Ruth Paredis, Femke Machtelinckx, Petra De Sutter, Ilse De Croo, Luc Leybaert, Dominic Stoop, et al.
Pagina's: 872 - 885 - Identification of modifier genes underlying intra-familial phenotypic variability in zebrafish OI models using whole exome sequencing and linkage analysis(2023)Volume: 7
Auteurs: Tamara Jarayseh, Adelbert De Clercq, Toon Rosseel, Mauro Alessio Milazzo, Andy Willaert, Paul Coucke
Aantal pagina's: 1 - Minocycline attenuates excessive DNA damage response and reduces ectopic calcification in pseudoxanthoma elasticum(2022)
Auteurs: Lukas Nollet, Matthias Van Gils, Andy Willaert, Paul Coucke, Olivier Vanakker
Pagina's: 1629 - 1638.e6 - Crispant screening in zebrafish as a promising approach for rapid functional screening of osteoporosis candidate genes and known genes for Osteogenesis Imperfecta(2022)
Auteurs: Sophie Debaenst, Hanna De Saffel, Jan Willem Bek, Adelbert De Clercq, Tamara Jarayseh, Lauren Sahd, Paul Coucke, Andy Willaert
Aantal pagina's: 1 - Exploring the mutational landscape of isolated congenital heart defects : an exome sequencing study using cardiac DNA(2022)
Auteurs: Ilse Meerschaut, Wouter Steyaert, Thierry Bové, Katrien Francois, Thomas Martens, Katya De Groote, Hans De Wilde, Laura Muiño Mosquera, Joseph Panzer, Kristof Vandekerckhove, et al.
- A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract(2022)
Auteurs: Tamara Jarayseh, Brecht Guillemyn, Hanna De Saffel, Jan Willem Bek, Sujatha Jagadeesh, Sofie Symoens, Fransiska Malfait, Delfien Syx, Filip Van Nieuwerburgh, Yannick Gansemans, et al.
Aantal pagina's: 1 - Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes(2021)
Auteurs: Jan Willem Bek, Chen Shochat, Adelbert De Clercq, Hanna De Saffel, Annekatrien Boel, Juriaan Metz, Frans Rodenburg, David Karasik, Andy Willaert, Paul Coucke
Pagina's: 1749 - 1764 - Rare modifier variants alter the severity of cardiovascular disease in pseudoxanthoma elasticum : identification of novel candidate modifier genes and disease pathways through mixture of effects analysis(2021)
Auteurs: Eva De Vilder, Ludovic Martin, Georges Lefthériotis, Paul Coucke, Filip Van Nieuwerburgh, Olivier Vanakker