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Octrooi

Drug-target identification by rapid selection of drug resistance mutations

The present invention relates to methods used in functional genomics that focus on gene function in a cell. The invention also relates to mutagenizing genes and generation of functional genetic mutants. The current invention also relates to methods for stimulus/drug-target identification. In addition, the invention relates to the generation of cell lines showing a functional phenotype, most notably stimulus/drug-resistant cell lines. The current invention further relates to methods for identification of mutations conferring this phenotype. The current invention further relates to said methods and provides for rapid selection methods to identify targets and to identify stimulus/drug-target interactions and to identify mutations conferring stimulus/drug-resistance, more specifically said methods comprise the use of CRISPR/Cas systems, components thereof or the like.
Octrooi-publicatienummer: WO2018032063
Jaar aanvraag: 2017
Jaar toekenning: 2019
Jaar van publicatie: 2018
Status: Aangevraagd
Technologiedomeinen: Biotechnologie
Gevalideerd voor IOF-sleutel: Ja
Toegewezen aan: Associatie KULeuven