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Octrooi
RESTORING PHOSPHORYLATION OF A NOVEL PINK1 SUBSTRATE TO TREAT PARKINSON'S DISEASE
The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.
Octrooi-publicatienummer: WO2014072412
Jaar aanvraag: 2013
Jaar toekenning: 2015
Jaar van publicatie: 2014
Status: Aangevraagd
URI: link to Espacenet
Technologiedomeinen: Biotechnologie
Gevalideerd voor IOF-sleutel: Ja
Toegewezen aan: Associatie KULeuven