< Terug naar vorige pagina

Octrooi

Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease

The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.
Octrooi-publicatienummer: US9879233
Jaar aanvraag: 2018
Jaar toekenning: 2018
Jaar van publicatie: 2018
Status: Toegewezen
Technologiedomeinen: Farmaceutische producten, Basismaterialen chemie
Gevalideerd voor IOF-sleutel: Ja
Toegewezen aan: Associatie KULeuven