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De pathogene rol van hemozoïne en endotheelactivatie in malaria geassocieerde acute respiratory distress syndrome

Boek - Dissertatie

Malaria is a severe disease and affects 200 million people with close to 600 000 deaths each year.Malarial symptoms range from non-lethal uncomplicated disease (e.g. fever, headache andnausea) to life-threatening complications, including cerebral malaria (CM) and malaria-associated
acute respiratory distress syndrome (MA-ARDS). Despite efficient antimalarial treatment,
complicated malaria has still a high mortality, and therefore a better understanding of thepathogenesis is crucial to improve therapies. In this project, we want to elucidate the roles andinterrelations of hemozoin (malaria pigment crystals) and sequestration on the microvascularendothelium in malarial complications. Sequestration is the cytoadhesion of parasite-infected redblood cells to the vascular endothelium. Based on preliminary data, we will define the crucialinterrelation between hemozoin production, local release by sequestering parasites, pathologicalendothelial activation and inflammation. To achieve this goal, we will usea set of unique transgenic parasites infecting mice, in vitro models with humancells and parasites, and an exceptional cohort of post mortem patient samples.
Jaar van publicatie:2020