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Early recognition and access to terminal complement blockers in patients with atypical HUS significantly improves their outcome : a case report

Tijdschriftbijdrage - Tijdschriftartikel

A 7-year-old boy presented with fever, pruritus and petechiae. Laboratory analysis revealed haemolytic anaemia with presence of schistocytes, thrombocytopenia and acute kidney injury, diagnostic for a thrombotic microangiopathy (TMA). Given the severe clinical presentation, the lack of evidence for verotoxin positive TMA and a normal ADAMTS13, treatment with eculizumab was started. This resulted in a complete resolution of the TMA course with recovery of the kidney injury. Workup revealed high titre of anti-factor H antibodies, diagnostic for an atypical haemolytic uremic syndrome (aHUS). Early recognition and treatment of TMA is essential to optimize the outcome of these patients.
Tijdschrift: BELGIAN JOURNAL OF PAEDIATRICS
ISSN: 2566-1558
Issue: 2
Volume: 25
Pagina's: 129 - 132
Jaar van publicatie:2023
Toegankelijkheid:Open