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Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients

Tijdschriftbijdrage - Tijdschriftartikel

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The latest strategies in the design and synthesis of metal-organic frameworks as heterogeneous catalysts in organic synthesis are compared with biocatalyzed transformations, as a step forward to a more convenient industrial production of pharmaceuticals. Relevant C−C and C−N bond forming reactions that are both chemo- and bio- catalyzed by synthetic MOFs and in vitro evolved and/or promiscuous enzymes with the aim of obtaining key bioactive scaffolds in a sustainable, competitive and cost-efficient manner, are thoroughly discussed in this mini review.
Tijdschrift: ChemCatChem
ISSN: 1867-3880
Issue: 23
Volume: 11
Pagina's: 5671 - 5685
Aantal pagina's: 15
Jaar van publicatie:2019
Trefwoorden:Fysische scheikunde