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A homogenized constrained mixture model of restenosis and vascular remodelling after balloon angioplasty

Tijdschriftbijdrage - Tijdschriftartikel

Restenosis is one of the main adverse effects of the treatment of atherosclerosis through balloon angioplasty or stenting. During the intervention, the arterial wall is overstretched, causing a cascade of cellular events and subsequent neointima formation. This mechanical stimulus and its mechanobiological effects can be reproduced in biomechanical simulations. The aim of these models is to predict the long-term outcome of these procedures, to help increase the understanding of restenosis formation and allow for in silico optimization of the treatment. We propose a predictive finite-element model of restenosis, using the homogenized constrained mixture modelling framework designed to model growth and remodelling in soft tissues. We compare the results to clinical observations in human coronary arteries and experimental findings in nonhuman primate models. We also explore the model’s clinical relevance by testing its response to different balloon loads and to the use of drug eluting balloons. The comparison of the results with experimental data shows the relevance of the model. We show its ability to predict both inward and outward remodelling as observed in vivo and we show the importance of an improved understanding of restenosis formation from a biomechanical point of view.
Tijdschrift: Journal of the Royal Society Interface
ISSN: 1742-5689
Issue: 178
Volume: 18
Jaar van publicatie:2021
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:1
Authors from:Higher Education
Toegankelijkheid:Open