Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis

New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.

Jaar van publicatie:1997

Trefwoorden:Protozoal diseases, Malaria, Plasmodium falciparum, Vectors, Mosquitoes, Anopheles, Drug development, Antimalarials, Ancistrocladaceae, Toegepaste scheikunde en chemische ingenieurswetenschappen, Organische en medische scheikunde, Farmacologie en toxicologie, Plantkunde