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From multidrug- to extensively drug-resistant tuberculosis: upward trends as seen from a 15-year nationwide study

Tijdschriftbijdrage - Tijdschriftartikel

BACKGROUND: Emergence of extensively drug-resistant tuberculosis (XDR-TB) represents an enormous challenge to Public Health globally. METHODS: Progression towards XDR-TB was investigated in Belgium, a country with a typically low TB incidence, by analyzing the magnitude, characteristics, and treatment success of multidrug-resistant tuberculosis (MDR-TB) through a population-based study from 1994 to 2008. RESULTS: Among the 174 MDR-TB patients, 81% were foreign-born, 48% of these being asylum seekers. Although the number of MDR-TB patients remained stable through the study period at around 15 new cases annually, frequencies of resistance of the patients' first MDR-TB isolate to second-line drugs increased, as well as the total number of antibiotics it was resistant to (p
Tijdschrift: PLoS ONE
ISSN: 1932-6203
Issue: 5
Volume: 8
Pagina's: e63128
Jaar van publicatie:2013
Trefwoorden:Bacterial diseases, Tuberculosis, Mycobacterium tuberculosis, Epidemiology, Trends, Drug resistance, Risk groups, Immigrants, Asylum seekers, Antibiotics, Second-line drugs, Asia, Europe-Central, Europe-East, Beijing genotype, Strains, Belgium, Europe-West
Toegankelijkheid:Open