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Unravelling ipsilateral interactions between left dorsal premotor and primary motor cortex: a proof of concept study

Tijdschriftbijdrage - Tijdschriftartikel

Few studies have identified the intrahemispheric functional connectivity between the ipsilateral dorsal premotor cortex (PMd) and the primary motor hand area (M1(hand)) due to technical limitations. In this proof-ofconcept study, a novel neuronavigated dsTMS set-up was employed, combining stimulation over left PMd and left M1(hand) using the edge of a butterfly coil and a small cooled-coil. This arrangement was warranted because coil (over)heating and inter coil distance are limiting factors when investigating connectivity between stimulation targets in close proximity and over a longer duration. The proposed set-up was designed to deal with these limitations. Specifically, the effect of four dual-site transcranial magnetic stimulation (dsTMS) protocols on twentyeight right-handed participants (12 males) was evaluated. These protocols differed in stimulus order, interstimulus interval and current direction induced in PMd. A structural scan with electric (E-)field modeling was obtained from seven participants prior to dsTMS, demonstrating that PMd and M1(hand) were effectively stimulated. Results indicate that one protocol, in which a latero-medial current was induced in PMd 2.8 ms prior to stimulation over M1(hand), induced a sex-mediated effect. In males, significant inhibition of motor-evoked potentials was identified, whereas females demonstrated a facilitatory effect that did not survive correction for multiple comparisons. E-field simulations revealed that the E-field induced by the coil targeting PMd was maximal in PMd, with weaker E-field strengths extending to regions beyond PMd. Summarizing, the current dsTMS set-up enabled stimulating at an inter-target distance of 35 mm without any indications of coil-overheating. (C) 2021 IBRO. Published by Elsevier Ltd. All rights reserved.
Tijdschrift: Neuroscience
ISSN: 0306-4522
Volume: 466
Pagina's: 36 - 46
Jaar van publicatie:2021
Trefwoorden:transcranial magnetic stimulation, dorsal premotor cortex, primary motor cortex, functional connectivity, brain modelling
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:1
Authors from:Higher Education
Toegankelijkheid:Closed