Titel Deelnemers "CLASSICAL PATHWAY ACTIVATION IN A PATIENT WITH LIGHT CHAIN DEPOSITION DISEASE AND ANGIOEDEMA" "Kathleen Claes, Michel Delforge, Hanna Peeters, Thea van der Velden, Joop Goertz, Bert van den Heuvel, Elena Volokhina" "FUNCTIONAL CHARACTERIZATION OF COMPLEMENT C2 MUTANTS IDENTIFIED IN PATIENTS WITH GLOMERULOPATHIES" "Aleksandra Urban, Elena Volokhina, Anna Felberg, Grzegorz Stasilojc, Anna M Blom, Bert van den Heuvel, Marcel Thiel, Stanislaw Oldziej, Santiago Rodriguez de Cordoba, Marcin Okroj" "NOVEL ASSAYS TO DISTINGUISH BETWEEN PROPERDIN-DEPENDENT AND PROPERDIN-INDEPENDENT C3 NEPHRITIC FACTORS PROVIDE INSIGHT FOR PROPERDIN-INHIBITING THERAPY" "Marloes Michels, Nicole van de Kar, Ramon van den Bos, Thea van der Velden, Sanne van Kraaij, Sebastian Sarlea, Valentina Gracchi, Michiel Oosterveld, Elena Volokhina, Bert van den Heuvel" "Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload" "Md Ruhul Amin, Ilayaraja Muthuramu, Joseph Pierre Abou Msallem, Mudit Mishra, Frank Jacobs, Bart De Geest" "SUCCESSFUL TREATMENT OF CDG SYMPTOMS BY GALACTOSE SUPPLEMENTATION IN PGM1 DEFICIENCY" "Tess Gadomski, Sunnie Wong, Tomas Honzik, Amanda Ackermann, Dirk Lefeber, Michael Gibson, Tamas Kozicz, Eva Morava" "Invasive pneumococcal disease results in renal thrombotic microangiopathy in mice: Influence of virulence factors and complement factor H deficiency" "D Westra, E van der Maten, E Volokhina, S van Selm, MI de Jonge, FJH van Opzeeland, BKT Willemsen, HBPM Dijkman, MC Pickering, S Florquin, M van der Flier, Bert van den Heuvel" "Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome" "Elena Volokhina, Nicole van de Kar, Grethe Bergseth, Thea van der Velden, Dineke Westra, Jack Wetzels, Bert van den Heuvel, Tom Eirik Mollnes" "Alternative pathway complement activation in C3 glomerulopathy" "Elena Volokhina, Joop Goertz, Thea van der Velden, Nicole van de Kar, Tom Eirik Mollnes, Bert van den Heuvel" "Exosomes: emerging roles in communication between blood cells and vascular tissues during atherosclerosis" "Heinrich Huber, Paul Holvoet" "Microvesicles, in general, and exosomes together with their delivered content in particular, are now being widely recognized as key players in atherosclerosis. We have previously reviewed the role of microvesicles in atherosclerosis pathogenesis, diagnosis and therapy. Here, we focus on the roles of exosomes and discuss their emergent role in mediating activation and response to inflammation, vessel infiltration and induction of coagulation. We will finally give an outlook to discuss novel detection techniques and systems biology based data analyses to investigate exosome-mediated cell-to-cell communication." "Design, synthesis, and biological evaluation of novel 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives as HIV-1 NNRTIs" "Tao Liu, Boshi Huang, Ye Tian, Xin Liang, Hong Liu, Huiqing Liu, Peng Zhan, Erik De Clercq, Christophe Pannecouque, Xinyong Liu" "Based on the hybridization of the privileged fragments in DABO and DAPY-typed HIV-1 NNRTIs, a novel series of 4-aminopiperidinyl-linked 3,5-disubstituted-1,2,6-thiadiazine-1,1-dione derivatives were designed, synthesized, and evaluated for their in vitro anti-HIV activities in MT-4 cells. Most of the target compounds showed weak inhibitory activity against WT HIV-1. In order to confirm the mode of action of the target compounds, representative compounds Ba8 and Bb8 were selected to perform the HIV-1 RT inhibitory assay. In this assay, Ba8 and Bb8 displayed good activity with IC50 values of 3.15 and 1.52 μm, respectively. Additionally, preliminary structure-activity relationships (SARs) analysis and molecular docking studies of newly synthesized compounds are also discussed."