Titel Deelnemers "ECJ 2014/9, Centro Hospitalar de Setúbal epe and Serviço de Utilizaço Comum dos Hospitais (SUCH) v. Eurest (Portugal)--Sociedade Europeia de Restaurantes Lda, 19 June 2014 (Case C-574/12)." "Tom Goffin" "Paul Valkema Blouw. Dutch Typography in the Sixteenth Century. The Collected Works of Paul Valkema Blouw. Edited by Ton Croiset van Uchelen and Paul Dijstelberge. (Library of the written word 18; The handpress world 12)" "Hubert Meeus" "Grand strategy in 10 words : a guide to great power politics in the 21st century" "Sven Biscop" "In a world that has returned to great power rivalry, understanding the grand strategy of these powers is crucial. This book introduces ten key terms for analysing grand strategy and shows how the world’s great powers – the United States, China, Russia and the European Union (EU) – shape their strategic decisions today. Outlining the steps needed for a less confrontational grand strategy and a more peaceful and stable world order, this lively and accessible introduction shows how the choices made in each of these ten areas will determine the course of world politics in the first half of the 21st century." "“18 shiji jinru quanqiu gonggong lingyu de Zhongguo dibao” 18世纪进入全球公共领域的中国《邸报》(The Chinese Gazette Joining the Global Public in the Eighteenth Century)" "Nicolas Standaert" "Early modern maps: To what extent are they metrically accurate? A contribution to the determination of metrical accuracy in some 16 th-century maps of Flanders)" "Frans Depuydt, L Decruynaere, A Heirman, J Theelen" "A mathematical similarity transformation is often applied to the study of metrical accuracy of early maps. Accidental major errors of some points in the early map affect the mean accuracy index of the map to a large extent. Therefore, here we propose to exclude these major errors until we made the similarity transformation. Finally we calculated the local inaccuracies of the cluster points. At this rate we obtain a more realistic and optimal expression of the map deformation. The latter is illustrated by some early maps of the County of Flanders. The Pourbus map (1571) becomes a much higher accuracy result (340 m) in comparison with the Flanders map of Mercator (1540) and Ortelius (1570) having an accuracy of respectively 815 m and 1,020 m." "Gender-affirming vaginoplasty : a comparison of algorithms, surgical techniques and management practices across 17 high-volume centers in North America and Europe" "Devin Coon, Shane D. Morrison, Martin P. Morris, Patrick Keller, Rachel Bluebond-Langner, Marci Bowers, Pierre Brassard, Marlon Buncamper, Daniel Dugi, Cecile Ferrando, Katherine M. Gast, Christine McGinn, Toby Meltzer, Stan Monstrey, Muejde Ozer, Melissa Poh, Thomas Satterwhite, Jess Ting, Lee Zhao, William M. Kuzon, Loren Schechter" "Background:Penile inversion vaginoplasty is the most common gender-affirming genital surgery performed around the world. Although individual centers have published their experiences, expert consensus is generally lacking. Methods:Semistructured interviews were performed with 17 experienced gender surgeons representing a diverse mix of specialties, experience, and countries regarding their patient selection, preoperative management, vaginoplasty techniques, complication management, and postoperative protocols. Results:There is significant consistency in practices across some aspects of vaginoplasty. However, key areas of clinical heterogeneity are also present and include use of extragenital tissue for vaginal canal/apex creation, creation of the clitoral hood and inner labia minora, elevation of the neoclitoral neurovascular bundle, and perioperative hormone management. Pathway length of stay is highly variable (1-9 days). Lastly, some surgeons are moving toward continuation or partial reduction of estrogen in the perioperative period instead of cessation. Conclusions:With a broad study of surgeon practices, and encompassing most of the high-volume vaginoplasty centers in Europe and North America, we found key areas of practice variation that represent areas of priority for future research to address. Further multi-institutional and prospective studies that incorporate patient-reported outcomes are necessary to further our understanding of these procedures." "Risk of Late Postoperative Recurrence of Crohn's Disease in Patients in Endoscopic Remission After Ileocecal Resection, Over 10 Years at Multiple Centers" "Peter Bossuyt" "BACKGROUND & AIMS: The risk of recurrence of Crohn's disease (CD) from 1 to 10 years after surgery despite initial endoscopic remission (late post-operative recurrence) is not clear. METHODS: We performed a retrospective study, at 3 inflammatory bowel disease (IBD) centers in France and Belgium, of all patients with CD (n = 86) undergoing an ileocecal resection with curative intent from 2006 through 2016 who did not have endoscopic evidence for recurrence (Rutgeerts score less than i2) at their baseline assessment. Postoperative recurrence after baseline endoscopy was defined as a composite endpoint of at least 1 of the following: clinical recurrence, IBD-related hospitalization, occurrence of bowel damage, need for endoscopic balloon dilatation of the anastomosis, and need to repeat the surgery. Risk of mucosal disease progression was studied as a secondary outcome. RESULTS: The median time between surgery and baseline endoscopy was 7 months (IQR, 5.7-9.5 months); 40 patients (46.5%) received medical prophylaxis in this period. The median follow-up time was 3.5 years (IQR, 1.6-5.3 years). Thirty-five patients (40.7%) had a late post-operative recurrence of CD, with a median time to disease recurrence after baseline endoscopy of 14.2 months (IQR, 6.3-26.1 months). Recurrence status did not differ significantly between patients with Rutgeerts scores of i0 (20/55) or i1 (15/31) at baseline (P = .28) and was independent of medical prophylaxis (16/40 with prophylactic therapy vs 19/46 without prophylactic therapy; P = .90). Mucosal disease progressed in 29 of the 71 patients (40.8%) with available data. We did not identify risk factors for late post-operative recurrence of CD or mucosal disease progression. CONCLUSIONS: Among patients with CD treated by ileocecal resection, 40% of patients had a late recurrence, despite initial endoscopic remission, after a median follow-up time of 3.5 years. Tight monitoring of these patients is recommended beyond 18 months." "Treatment and outcome of 370 cases with spontaneous or post-laser twin anemia-polycythemia sequence managed in 17 fetal therapy centers" "Liesbeth Lewi" "OBJECTIVE: To investigate the antenatal management and outcome in a large international cohort of monochorionic twin pregnancies with spontaneous or post-laser twin anemia-polycythemia sequence (TAPS). METHODS: This study analyzed data of monochorionic twin pregnancies diagnosed antenatally with spontaneous or post-laser TAPS in 17 fetal therapy centers, recorded in the TAPS Registry between 2014 and 2019. Antenatal diagnosis of TAPS was based on fetal middle cerebral artery peak systolic velocity > 1.5 multiples of the median (MoM) in the TAPS donor and" "Contributions of the US Centers for Disease Control and Prevention in implementing the Global Health Security Agenda in 17 partner countries" "Arthur G Fitzmaurice, Michael Mahar, Leah F Moriarty, Maureen Bartee, Mitsuaki Hirai, Wenshu Li, A Russell Gerber, Jordan W Tappero, Rebecca Bunnell, Marc-Alain Widdowson" "The Global Health Security Agenda (GHSA), a partnership of nations, international organizations, and civil society, was launched in 2014 with a mission to build countries' capacities to respond to infectious disease threats and to foster global compliance with the International Health Regulations (IHR 2005). The US Centers for Disease Control and Prevention (CDC) assists partner nations to improve IHR 2005 capacities and achieve GHSA targets. To assess progress through these CDC-supported efforts, we analyzed country activity reports dating from April 2015 through March 2017. Our analysis shows that CDC helped 17 Phase I countries achieve 675 major GHSA accomplishments, particularly in the cross-cutting areas of public health surveillance, laboratory systems, workforce development, and emergency response management. CDC's engagement has been critical to these accomplishments, but sustained support is needed until countries attain IHR 2005 capacities, thereby fostering national and regional health protection and ensuring a world safer and more secure from global health threats." "RAS testing in metastatic colorectal cancer: excellent reproducibility amongst 17 Dutch pathology centers." "Els Dequeker" "In 2013 the European Medicine Agency (EMA) restricted the indication for anti-EGFR targeted therapy to metastatic colorectal cancer (mCRC) with a wild-type RAS gene, increasing the need for reliable RAS mutation testing. We evaluated the completeness and reproducibility of RAS-testing in the Netherlands. From 17 laboratories, tumor DNA of the first 10 CRC cases tested in 2014 in routine clinical practice was re-tested by a reference laboratory using a custom next generation sequencing panel. In total, 171 CRC cases were re-evaluated for hotspot mutations in KRAS, NRAS and BRAF. Most laboratories had introduced complete RAS-testing (65%) and BRAF-testing (71%) by January 2014. The most employed method for all hotspot regions was Sanger sequencing (range 35.7 - 49.2%). The reference laboratory detected all mutations that had been found in the participating laboratories (n = 92), plus 10 additional mutations. This concerned three RAS and seven BRAF mutations that were missed due to incomplete testing of the participating laboratory. Overall, the concordance of tests performed by both the reference and participating laboratory was 100% (163/163; κ-static 1.0) for RAS and 100% (144/144; κ-static 1.0) for BRAF. Our study shows that RAS and BRAF mutations can be reproducibly assessed using a variety of testing methods."